Handling time varying confounding in observational research
نویسندگان
چکیده
منابع مشابه
Handling time varying confounding in observational research.
Many exposures of epidemiological interest are time varying, and the values of potential confounders may change over time leading to time varying confounding. The aim of many longitudinal studies is to estimate the causal effect of a time varying exposure on an outcome that requires adjusting for time varying confounding. Time varying confounding affected by previous exposure often occurs in pr...
متن کاملAdjusting for Time-Varying Confounding in Survival Analysis
Adjusting for Time-Varying Confounding in Survival Analysis In this paper we illustrate how directly including endogenous time-varying confounders in the model of the effect of an exposure on a response can lead to bias in discrete time survival analysis. An alternative to this method is Hernán, Brumback and Robins’ (1999) use of sample weights to adjust for endogenous time-varying confounding....
متن کاملResidual confounding in observational studies.
To the Editor:—I read the study by Fellahi JL et al. titled “Perioperative use of dobutamine in cardiac surgery and adverse cardiac outcome” with great interest. This study showed that the use of dobutamine was associated with adverse outcomes in adult cardiac surgery, and the authors concluded that these results suggest that dobutamine should only be administered when the benefit is judged to ...
متن کاملConfounding in Observational Studies Explained
Practical and ethical constraints mean that many clinical and/or epidemiological questions cannot be answered through the implementation of a randomized controlled trial. Under these circumstances, observational studies are often required to assess relationships between certain exposures and disease outcomes. Unfortunately, observational studies are notoriously vulnerable to the effect of diffe...
متن کاملResidual Confounding in Observational Studies
To the Editor:—I read the study by Fellahi JL et al. titled “Perioperative use of dobutamine in cardiac surgery and adverse cardiac outcome” with great interest. This study showed that the use of dobutamine was associated with adverse outcomes in adult cardiac surgery, and the authors concluded that these results suggest that dobutamine should only be administered when the benefit is judged to ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMJ
سال: 2017
ISSN: 0959-8138,1756-1833
DOI: 10.1136/bmj.j4587